Pregnant mares secrete the hormone from their endometrial cups between 40 and 130 days into their gestation, and once collected, it has been used to artificially induce estrus in female sheep, goats, cattle, and swine. Despite being less pure than pituitary extracts from sheep, goats or swine, PMSG tends to be used because of its longer circulatory half-life. In equids PMSG has only LH like activity, but in other species it has activity like both follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Equine CG, like all glycoprotein hormones, is composed of two dissimilar subunits named alpha and beta. The alpha subunit is common to all glycoprotein hormones (LH, FSH, TSH, CG). The beta subunits are hormone-specific and are responsible for receptor binding specificity, although CG binds to the same Luteinizing hormone/choriogonadotropin receptor as LH. In the equids (horses, donkeys, zebras), the placental CGs and pituitary LH are expressed from the same gene and thus have the same protein sequence, differing only by their carbohydrate side-chains (particularly in their respective beta subunits).
Generic Name: Serum Gonadotrophin for Injection
Trade Name: Pregnant Horse Serum
Veterinary Medicine Quality Standard 2017
Pregnant mare's serum gonadotropin
This product is white freeze-dried block-shaped substance or powder.
This product has follicle-stimulating hormone (FSH) and luteinizing (LH)-like effects. It can promote follicle maturation, ovulation and corpus luteum production, and stimulate the corpus luteum to secrete progesterone in female livestock. It can promote the secretion of androgen in testicular stromal cells and promote the formation of spermatozoa in male livestock.
Mainly used to induce estrus and promote follicle development in dams; also used for superovulation during embryo transfer.
[Usage and Dosage]
Subcutaneous, intramuscular injection: one dose. For estrus: horses & cattle - 1,000~2,000 units; sheep - 100~500 units; pigs - 200~800 units; dogs - 25~200 units; cats - 25~100 units; rabbits & otters - 30 ~50 units. For superovulation: cows - 2,000~4,000 units; ewe - 600~1,000 units.
Diluted with 2-5ml sterile saline before use.
(1)Avoid long-term use to avoid antibodies and inhibit gonadotropin function.
(2)This product solution is extremely unstable, and is not heat-resistant. It should be used in a short time.
Individual animals may have allergies. Routine treatment with dexamethasone or epinephrine is sufficient.
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