Progesterone is a hormone produced by the ovaries and placenta that helps to maintain pregnancy. It's main effects on tissues inside the body include: induction of an elaborate network of glands (endometrial glands) in the uterus to help provide nutrition to the early conceptus(baby) and become the maternal side of the placenta (connection between baby and mom). During pregnancy, it helps keep the uterine muscle layers relatively quiet so as not to disrupt a pregnancy. It also helps suppress the mother's immune response to its "foreign" baby as the baby grows and develop it's own immune system. Progesterone also provides the stimulus to development of the glandular portions of the mammary glands (breast tissue)- it along with estrogen and other hormones, produce the changes to breast tissue after puberty, throughout pregnancy and during nursing to allow these tissues to produce milk for babies. Progesterone enhances the effects of estrogen on the female's brain to provide outward signs of estrus ("heat"). This is one of the reasons why a bitch's first heat can be silent or go unobserved when there was not sufficient progesterone to prime the brain prior to the secretion of estrogen. Progesterone, also like other steroids, can reduce the body's sensitivity to hormones like insulin that are helpful to glucose control- this is helpful to a pregnant mother with young, growing babies that require large amounts of energy as they develop into late pregnancy, but can lead to poor glucose control (gestational diabetes) in some bitches.
Generic Name: Progesterone Injection
This product is a colorless or light yellow clear oily liquid.
Based on the fuction of estrogen, progesterone can promote the development of the endometrium and glands, inhibit the contraction of uterine muscles, weaken the response of uterine muscle to oxytocin, and ensure tocolysis. The feedback mechanism inhibits the secretion of luteinizing hormone from the anterior pituitary and inhibits estrus and ovulation. In addition, it works together with estrogen to stimulate the development of breast acini and preparation for lactation
Used for habitual or threatened abortions and estrus during estrus, delays ovulation in cattle and horses, and inhibits estrus in dam.
[Usage and Dosage]
Intramuscular injection; one dose, horse & cow - 1 ~ 2ml; sheep & pig - 0.3 ~ 0.5ml; dog - 0.04 ~ 0.1ml.
No adverese reactions were found with the recommended usage and doages.
(1) Long-term use can prolong pregnancy
(2)Do not use in lactating cows
30 days for cows, sheep, and pigs
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